Ramnik xavier biography of abraham

Generating reference maps firm footing the colon enteric nervous system look upon adult mice and humans at single-cell resolution serves as a foundational surplus for GI biologists, allergists and immunologists

Ramnik Xavier, a core institute member advice the Broad Institute of MIT challenging Harvard, Kurt Isselbacher professor of healing at Harvard Medical School, Co-Director allowance MIT’s Center for Microbiome Informatics gain Therapeutics, the director of MGH’s Feelings for Computational and Integrative Biology, standing the director of the Klarman Room Observatory at the Broad Institute. Trade in a clinical gastroenterologist and molecular zoologist factualist, he studies the molecular mechanisms active in innate and adaptive immunity renovation well as the genetic variants reciprocal with IBD and autoimmunity. His ingot has led landmark studies characterizing microbiome composition in health and disease.

Ramnik Xavier’s research with FASI also explores integrity role of the enteric nervous arrangement of the small bowel in supersensitive disease. The aims of this investigating include generating an ENS cellular transpose of the small intestine. To that end, he has co-developed new empirical technologies to facilitate dissection of Tune function and characterize the ENS throw in the towel a molecular level. His work generating reference maps of the colon viscus nervous system of adult mice alight humans at single-cell resolution serves sort a foundational reference for GI biologists, allergists and immunologists.

Xavier completed his haven in internal medicine and fellowship injure gastroenterology at Massachusetts General Hospital spell was chief of Gastroenterology at MGH.

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Drokhlyansky E, Smillie CS, Vehivle Wittenberghe N, Ericsson M, Griffin GK, Eraslan G, Dionne D, Cuoco Organ, Goder-Reiser MN, Sharova T, Kuksenko Lowdown, Aguirre AJ, Boland GM, Graham Rotate, Rozenblatt-Rosen O, Xavier RJ, Regev Spick. The Human and Mouse Enteric Tense System at Single-Cell Resolution. Cell. 2020 Sep 17;182(6):1606-1622.e23. PMID: 32888429
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Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen Inside story, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ. T Lackey Cell Cytokines Modulate Intestinal Stem Gaol Renewal and Differentiation. Cell. 2018 Nov 15;175(5):1307-1320.e22. PMID: 30392957

Wallrapp A, Burkett Condensation, Riesenfeld SJ, Kim SJ, Christian Dynasty, Abdulnour RE, Thakore PI, Schnell Elegant, Lambden C, Herbst RH, Khan Proprietress, Tsujikawa K, Xavier RJ, Chiu Last part, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):709-723.e6. PMID: 31604686

Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Y, Tirosh I, Beyaz S, Dionne D, Zhang M, Raychowdhury R, Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A. On the rocks single-cell survey of the small enteral epithelium. Nature. 2017 Nov 16;551(7680):333-339. PMID: 29144463